guanyl-nucleotide exchange factor activity [GO_0005085]

Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

Tags:

Class
GO

guanyl-nucleotide exchange factor activity

ID: GO_0005085

Class

Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

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Classification

GTPase regulator activity

Relationships

negatively regulates: GDP binding
positively regulates: GTP binding

Alternative Names

Synonym	Scope	Reference
Rab guanyl-nucleotide exchange factor activity	narrow synonym
Ras guanyl-nucleotide exchange factor activity	narrow synonym
cAMP-dependent guanyl-nucleotide exchange factor activity	narrow synonym
ARF guanyl-nucleotide exchange factor activity	narrow synonym
Ral guanyl-nucleotide exchange factor activity	narrow synonym
Ran guanyl-nucleotide exchange factor activity	narrow synonym
Rap guanyl-nucleotide exchange factor activity	narrow synonym
Sar guanyl-nucleotide exchange factor activity	narrow synonym
Rac guanyl-nucleotide exchange factor activity	narrow synonym
GNRP	narrow synonym
Rho guanyl-nucleotide exchange factor activity	narrow synonym
Rho guanine nucleotide exchange factor	exact synonym
GDS	exact synonym
guanyl-nucleotide release factor activity	exact synonym
GEF	exact synonym
RhoGEF	exact synonym
guanyl-nucleotide releasing factor	exact synonym
GDP-dissociation stimulator activity	exact synonym

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an> "iri": "http://purl.obolibrary.org/obo/GO_0019003", "types": [ "Entity", "Class" ], "short_form": "GO_0019003", "label": "GDP binding" } }, { "relation": { "iri": "http://purl.obolibrary.org/obo/RO_0002213", "label": "positively regulates", "type": "positively_regulates" }, "object": { "symbol": "", "iri": "http://purl.obolibrary.org/obo/GO_0005525", "types": [ "Entity", "Class" ], "short_form": "GO_0005525", "label": "The receptor:G-protein complex binds GTP" } } ], "xrefs": [], "anatomy_channel_image": [], "pub_syn": [ { "synonym": { "scope": "has_exact_synonym", "label": "GEF", "type": "" }, "pub": { "core": { "symbol": "", "iri": "http://flybase.org/reports/Unattributed", "types": [ "Entity", "Individual", "pub" ], "short_form": "Unattributed", "label": "" }, "FlyBase": "", "PubMed": "", "DOI": "" } }, { "synonym": { "scope": "has_narrow_synonym", "label": "Rab guanyl-nucleotide exchange factor activity", "type": "" }, "pub": { "core": { "symbol": "", "iri": 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"types": [ "Entity", "Individual", "pub" ], "short_form": "Unattributed", "label": "" }, "FlyBase": "", "PubMed": "", "DOI": "" } }, { "synonym": { "scope": "has_exact_synonym", "label": "guanyl-nucleotide releasing factor", "type": "" }, "pub": { "core": { "symbol": "", "iri": "http://flybase.org/reports/Unattributed", "types": [ "Entity", "Individual", "pub" ], "short_form": "Unattributed", "label": "" }, "FlyBase": "", "PubMed": "", "DOI": "" } }, { "synonym": { "scope": "has_narrow_synonym", "label": "Ral guanyl-nucleotide exchange factor activity", "type": "" }, "pub": { "core": { "symbol": "", "iri": "http://flybase.org/reports/Unattributed", "types": [ "Entity", "Individual", "pub" ], "short_form": "Unattributed", "label": "" }, "FlyBase": "", "PubMed": "", "DOI": "" } }, { "synonym": { "scope": "has_narrow_synonym", "label": "Rac guanyl-nucleotide exchange factor activity", "type": "" }, "pub": { "core": { "symbol": "", "iri": "http://flybase.org/reports/Unattributed", "types": 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