histone H3K27 dimethyltransferase activity [GO_0140952]

Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.
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histone H3K27 dimethyltransferase activity

ID: GO_0140952

Class

Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2.

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.

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Classification

Alternative Names

Synonym Scope Reference
histone H3-K27 dimethylation broad synonym
histone H3K27 dimethylation broad synonym
histone H3K27 mono/dimethylase activity exact synonym
histone H3K27 dimethylase activity exact synonym
histone lysine N-dimethyltransferase activity (H3-K27 specific) exact synonym
histone H3-K27 dimethylase activity exact synonym